MDSCs in infectious diseases: regulation, roles, and readjustment. - Institut Pasteur Access content directly
Journal Articles Cancer Immunology, Immunotherapy Year : 2019

MDSCs in infectious diseases: regulation, roles, and readjustment.

Anurag Singh
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Abstract

Many pathogens, ranging from viruses to multicellular parasites, promote expansion of MDSCs, which are myeloid cells that exhibit immunosuppressive features. The roles of MDSCs in infection depend on the class and virulence mechanisms of the pathogen, the stage of the disease, and the pathology associated with the infection. This work compiles evidence supported by functional assays on the roles of different subsets of MDSCs in acute and chronic infections, including pathogen-associated malignancies, and discusses strategies to modulate MDSC dynamics to benefit the host.
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pasteur-01969805 , version 1 (04-01-2019)

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Anca Dorhoi, Estibaliz Glaría, Thalía Garcia-Tellez, Natalie E Nieuwenhuizen, Gennadiy Zelinskyy, et al.. MDSCs in infectious diseases: regulation, roles, and readjustment.. Cancer Immunology, Immunotherapy, 2019, 68 (4), pp.673-685. ⟨10.1007/s00262-018-2277-y⟩. ⟨pasteur-01969805⟩
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