The ENIGMA Consortium : large-scale collaborative analyses of neuroimaging and genetic data - Institut Pasteur
Article Dans Une Revue Brain imaging and behavior (Brain Imaging Behav) Année : 2014

The ENIGMA Consortium : large-scale collaborative analyses of neuroimaging and genetic data

Paul M. Thompson (1, 2) , Jason L. Stein (3) , Sarah Medland (4) , Derrek D Hibar (2) , Alejandro Arias Vasquez (5) , Miguel E. Renteria (4) , Roberto Toro (6) , Neda Jahanshad (2) , Gunter Schumann (7) , Barbara Franke (5) , Margaret J. Wright (4) , Nicholas G. Martin (4) , Ingrid Agartz (8, 9, 10) , Martin Alda (11) , Saud Alhusaini (12, 13) , Laura Almasy (14) , Jorge Almeida (11, 15) , Kathryn Alpert (16) , Nancy C. Andreasen (17) , Ole A. Andreassen (18, 19) , Liana G. Apostolova (3) , Katja Appel (20, 21) , Nicola J. Armstrong (22) , Benjamin Aribisala (23, 24) , Mark E. Bastin (23, 24) , Michael Bauer (25) , Carrie E. Bearden (26) , Ørjan Bergmann (27) , Elisabeth B. Binder (28) , John Blangero (14) , Henry J. Bockholt (17) , Erlend Bøen (27, 18) , Catherine Bois (29, 23) , Dorret I. Boomsma (30, 31) , Tom Booth (32) , Ian J. Bowman (2) , Janita Bralten (33, 5) , Rachel M. Brouwer (34, 35) , Han G. Brunner (5, 36) , David G. Brohawn (37, 38) , Randy L. Buckner (39, 40) , Jan Buitelaar (41, 33) , Kazima M Bulayeva (42, 43) , Juan R. Bustillo (44) , Vince D. Calhoun (45, 46) , Dara M. Cannon (47) , Rita M. Cantor (48, 49) , Melanie A. Carless (14) , Xavier Caseras (50) , Gianpiero L. Cavalleri (12) , M. Mallar Chakravarty (51, 52) , Kiki D. Chang (53) , Christopher R. K. Ching (2) , Andrea Christoforou (19, 54) , Sven Cichon (55, 56, 57) , Vincent P. Clark (44) , Patricia Conrod (7, 58) , Giovanni Coppola (26, 3) , Benedicto Crespo-Facorro (59, 60) , Joanne E Curran (14) , Michael Czisch (28) , Ian J. Deary (61) , Eco J. C. de Geus (30, 31) , Anouk den Braber (30) , Giuseppe Delvecchio (7) , Chantal Depondt (62) , Lieuwe de Haan (31) , Greig I. de Zubicaray (63) , Danai Dima (7) , Rali Dimitrova (29, 23) , Srdjan Djurovic (8, 19, 18) , Hongwei Dong (2) , Gary Donohoe (47, 64) , Ravindranath Duggirala (14) , Thomas D. Dyer (14) , Stefan Ehrlich (65, 66) , Carl Johan Ekman (9, 10) , Torbjørn Elvsåshagen (27, 18) , Louise Emsell (47) , Susanne Erk (67) , Thomas Espeseth (19) , Jesen Fagerness (65) , Scott Fears (26) , Iryna Fedko (30) , Guillén Fernández (33, 5) , Simon E. Fisher (33, 68) , Tatiana Foroud (69) , Peter T. Fox (70, 71) , Clyde Francks (68, 33) , Sophia D Frangou (72) , Eva Maria Frey (73) , Thomas Frodl (73, 64) , Vincent Frouin (74) , Hugh Garavan (75) , Sudheer Giddaluru (76, 54) , David C. Glahn (77, 78) , Beata Godlewska (79) , Rita Z. Goldstein (80) , Randy L. Gollub (81, 65) , Hans J. Grabe (20, 82, 83, 21) , Oliver Grimm (84) , Oliver Gruber (85) , Tulio Guadalupe (86, 68) , Raquel E. Gur (87) , Ruben C. Gur (87) , Harald H. H. Göring (14) , Saskia Hagenaars (29, 23) , Tomas Hajek (11) , Geoffrey B. Hall (88) , Jérémy Hall (23, 29) , John Hardy (89) , Catharina A. Hartman (90) , Johanna Hass (66) , Sean N. Hatton (91) , Unn K. Haukvik (92, 19) , Katrin Hegenscheid (20, 21) , Andreas Heinz (67) , Ian B. Hickie (91) , Beng-Choon Ho (17) , David Hoehn (28) , Pieter J. Hoekstra (90) , Marisa Hollinshead (38, 40) , Avram J. Holmes (38, 40) , Georg Homuth (20, 21) , Martine Hoogman (5) , L. Elliot Hong (93) , Norbert Hosten (20, 21) , Jouke-Jan Hottenga (30) , Hilleke E. Hulshoff Pol (34) , Kristy S. Hwang (94, 95) , Clifford R. Jack Jr (96) , Mark Jenkinson (97) , Caroline Johnston (7, 98) , Erik G. Jönsson (9, 10) , René S. Kahn (34, 35) , Dalia Kasperaviciute (89) , Sinead Kelly (99, 64) , Sungeun Kim (100) , Peter M. Kochunov (101) , Laura Koenders (31, 30) , Bernd Krämer (85) , John B. J. Kwok (102, 103) , Jim Lagopoulos (91) , Gonzalo Laje (104) , Mikael Landén (105, 9) , Bennett A. Landman (106) , John Lauriello (107) , Stephen M. Lawrie (29, 23) , Phil H. Lee (108, 38) , Stephanie Le Hellard (19, 54) , Hervé Lemaître (109, 110, 111, 112) , Cassandra D. Leonardo (2) , Chiang-Shan Li (113) , Benny Liberg (9) , David C. Liewald (61) , Xinmin Liu (114, 115) , Lorna M. Lopez (23) , Eva Loth (7) , Anbarasu Lourdusamy (116) , Michelle Luciano (23) , Fabio Macciardi (117, 118) , Marise W. J. Machielsen (31) , Glenda M. MacQueen (119, 120) , Ulrik F. Malt (18, 121) , René Mandl (34) , Dara S. Manoach (38) , Jean-Luc Martinot (122, 112, 110, 109) , Mar Matarin (89) , Karen Mather (123) , Manuel Mattheisen (124, 55, 125) , Morten Mattingsdal (19, 126) , Andreas Meyer-Lindenberg (127) , Colm McDonald (47) , Andrew McIntosh (23, 29) , Francis J. McMahon (114) , Katie L. McMahon (128, 129) , Eva Meisenzahl (130) , Ingrid Melle (19, 27) , Yuri Milaneschi (131, 31, 30) , Sebastian Mohnke (67) , Grant W. Montgomery (132) , Derek W. Morris (64) , Eric K. Moses (133, 14) , Bryon A. Mueller (134) , Susana Muñoz Maniega (23, 24) , Thomas W. Mühleisen (55, 56) , Bertram Müller-Myhsok (28, 135) , Benson Mwangi (136) , Matthias Nauck (20, 21) , Kwangsik Nho (137) , Thomas E. Nichols (138) , Lars-Göran Nilsson (139, 140) , Allison C. Nugent (114) , Lars Nyberg (141, 141) , Rene L. Olvera (142) , Jaap Oosterlaan (143, 30) , Roel A. Ophoff (144, 49, 34, 35) , Massimo Pandolfo (62) , Melina Papalampropoulou-Tsiridou (29, 23) , Martina Papmeyer (23, 29) , Tomas Paus (145, 146) , Zdenka Pausova (147) , Godfrey D. Pearlson (20, 113, 21) , Brenda W. Penninx (31, 30) , Charles P. Peterson (14) , Andrea Pfennig (25) , Mary Phillips (148, 149) , G. Bruce Pike (145, 120) , Jean-Baptiste Poline (150, 151) , Steven G. Potkin (152) , Benno Pütz (28) , Adaikalavan Ramasamy (153, 154, 155, 89) , Jerod Rasmussen (152) , Marcella Rietschel (127, 84) , Mark Rijpkema (33) , Shannon L. Risacher (100, 156) , Joshua L. Roffman (39) , Roberto Roiz-Santiañez (59, 60, 157) , Nina Romanczuk-Seiferth (67) , Emma J. Rose (158) , Natalie A. Royle (159, 24, 23) , Dan Rujescu (160) , Mina Ryten (161, 89, 162) , Perminder Sachdev (163, 102) , Alireza Salami (141, 141, 164) , Theodore D. Satterthwaite (87) , Jonathan Savitz (87, 165, 166) , Andrew J. Saykin (67) , Cathy Scanlon (47) , Lianne Schmaal (30) , Hugo G. Schnack (35) , Andrew J. Schork (167, 168) , S. Charles Schulz (169) , Remmelt Schür (35) , Larry Seidman (170, 171) , Li Shen (100) , Jody M. Shoemaker (45) , Andrew Simmons (7, 172, 173) , Sanjay Sisodiya (174) , Colin Smith (175, 23) , Jordan W. Smoller (176, 39, 108) , Jair C. Soares (136) , Scott R. Sponheim (177, 169) , Emma Sprooten (77) , John M. Starr (61, 23, 178) , Vidar M. Steen (54, 19) , Stephen Strakowski (179, 180) , Lachlan Strike (132) , Jessika Sussmann (29, 23) , Philipp G. Sämann (28) , Alexander Teumer (21) , Arthur W. Toga (1, 2) , Diana Tordesillas-Gutierrez (181, 60, 157, 59) , Daniah Trabzuni (155, 89, 182) , Sarah Trost (85) , Jessica Turner (183, 45) , Martijn D. van den Heuvel (35) , Nic J. van Der Wee (184, 185) , Kristel van Eijk (34, 35) , Theo G. M. van Erp (152) , Neeltje E. M. van Haren (35) , Dennis van’t Ent (186) , Marie-Jose van Tol (90) , Maria C. Valdés Hernández (23) , Dick J. Veltman (30) , Amelia Versace (149) , Henry Völzke (187, 20) , Robert Walker (188) , Henrik Walter (67, 189) , Lei Wang (16) , Joanna Wardlaw (23, 159) , Michael E. Weale (162) , Michael W. Weiner (190) , Wei Wen (123) , Lars T. Westlye (191, 19) , Heather C. Whalley (29, 192) , Christopher D. Whelan (12) , Tonya White (193) , Anderson M. Winkler (97, 113) , Katharina Wittfeld (82) , Girma Woldehawariat (114) , Christiane Wolf (28) , David Zilles (85) , Marcel P. Zwiers (33) , Anbupalam Thalamuthu (123) , Peter R. Schofield (103, 102) , Nelson B. Freimer (194, 49) , Natalia S. Lawrence (195) , Wayne Drevets (196)
1 LONI - Laboratory of Neuro Imaging [Los Angeles]
2 Keck School of Medicine [Los Angeles]
3 David Geffen School of Medicine [Los Angeles]
4 QIMR Berghofer Medical Research Institute
5 Radboud University Medical Center [Nijmegen]
6 Génétique Humaine et Fonctions Cognitives
7 Institute of Psychiatry, Psychology & Neuroscience, King's College London
8 UiO - University of Oslo
9 Karolinska Institutet [Stockholm]
10 Karolinska University Hospital [Stockholm]
11 Dalhousie University [Halifax]
12 RCSI - Royal College of Surgeons in Ireland
13 McGill University = Université McGill [Montréal, Canada]
14 Texas Biomedical Research Institute [San Antonio, TX]
15 University of Pittsburgh School of Medicine
16 Northwestern University [Evanston]
17 University of Iowa [Iowa City]
18 Oslo University Hospital [Oslo]
19 NORMENT - Norwegian Centre for Mental Disorders Research [Oslo]
20 Universität Greifswald - University of Greifswald
21 Interfaculty Institute for Genetics and Functional Genomics
22 School of Mathematics and Statistics
23 Edin. - University of Edinburgh
24 Brain Research Imaging Centre, Imaging Sciences
25 University Hospital Carl Gustav Carus [Dresden, Germany]
26 Semel Institute for Neuroscience and Human Behavior [Los Angeles, Ca]
27 Institute of Clinical Medicine [Oslo]
28 Max Planck Institute of Psychiatry
29 Royal Hospital for Sick Children [Edinburgh]
30 VU University Medical Center [Amsterdam]
31 Department of General Practice/EMGO Institute
32 CCACE - Centre for Cognitive Ageing and Cognitive Epidemiology
33 Donders Institute for Brain, Cognition and Behaviour
34 UMCU - University Medical Center [Utrecht]
35 Brain Centre Rudolf Magnus [Utrecht]
36 Department of Human Genetics [Nijmegen]
37 Psychiatric and Neurodevelopmental Genetics Unit
38 Massachusetts General Hospital [Boston]
39 Department of Psychiatry [Boston]
40 Harvard University
41 Karakter Child and Adolescent Psychiatry University Centre [Nijmegen]
42 N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119333, Russia
43 RAS - Russian Academy of Sciences [Moscow]
44 The University of New Mexico [Albuquerque]
45 The Mind Research Network
46 ECE Department - Department of Electrical and Computer Engineering [Albuquerque]
47 NUI Galway - National University of Ireland [Galway]
48 Center for Neurobehavioral Genetics
49 UCLA - University of California [Los Angeles]
50 Institute of Psychological Medicine and Clinical Neurosciences
51 CAMH - Centre for Addiction and Mental Health [Toronto]
52 IBBME - Institute of Biomaterials and Biomedical Engineering [Toronto, ON, Canada]
53 Stanford School of Medicine [Stanford]
54 UiB - University of Bergen
55 Universität Bonn = University of Bonn
56 Jülich Research Centre
57 Unibas - Université de Bâle = University of Basel = Basel Universität
58 Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital [Montreal, Canada]
59 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
60 IFIMAV - Fundación Marqués de Valdecilla-Instituto de Formación e Investigación Marqués de Valdecilla
61 Centre for Cognitive Ageing and Cognitive Epidemiology
62 HUB-ULB - Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis
63 School of Psychology, University of Queensland
64 Trinity College Dublin
65 MGH - Department of Psychiatry Massachusetts General Hospital
66 TU Dresden - Technische Universität Dresden = Dresden University of Technology
67 Charité - UniversitätsMedizin = Berlin University Medicine
68 Max Planck Institute for Psycholinguistics
69 Department of Medical and Molecular Genetics
70 UTHealth - The University of Texas Health Science Center at Houston
71 South Texas Veterans Health Care System, San Antonio, Texas 78229, USA
72 MSSM - Icahn School of Medicine at Mount Sinai [New York]
73 University Hospital Regensburg
74 NEUROSPIN - Service NEUROSPIN
75 University of Vermont [Burlington]
76 Haukeland University Hospital
77 Dpt of Psychiatry [New Haven]
78 Hartford Hospital
79 University of Oxford
80 Laboratory of Molecular Neuropsychiatry
81 Athinoula A. Martinos Center for Biomedical Imaging
82 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen
83 HELIOS Klinikum Stralsund Hanseatic
84 University of Heidelberg, Medical Faculty
85 Georg-August-University = Georg-August-Universität Göttingen
86 IMPRS - International Max Planck Research School for Language Sciences
87 University of Pennsylvania
88 McMaster University [Hamilton, Ontario]
89 UCL Queen Square Institute of Neurology
90 UMCG - University Medical Center Groningen [Groningen]
91 Brain and Mind Research Institute
92 Diakonhjemmet Hospital
93 University of Maryland School of Medicine
94 Oakland University
95 University of Rochester School of Medicine
96 Mayo Clinic [Rochester]
97 FMRIB - Oxford Centre for Functional Magnetic Resonance Imaging of the Brain
98 South London and Maudsley NHS Foundation Trust
99 FIMM - Institute for Molecular Medicine Finland [Helsinki]
100 Indiana University School of Medicine
101 University of Maryland [Baltimore]
102 UNSW - University of New South Wales [Sydney]
103 NeuRA - Neuroscience Research Australia
104 UMBC - University of Maryland [Baltimore County]
105 GU - Göteborgs Universitet = University of Gothenburg
106 Vanderbilt University [Nashville]
107 Mizzou - University of Missouri [Columbia]
108 BROAD INSTITUTE - Broad Institute of MIT and Harvard
109 UCP - Université de Cergy Pontoise
110 SHFJ - Service Hospitalier Frédéric Joliot
111 U1000 - Neuroimagerie en psychiatrie
112 SCLIN - Clinatec - Centre de recherche biomédicale Edmond J.Safra
113 Department of Neuroscience, Yale University School of Medicine
114 NIH - National Institutes of Health [Bethesda, MD, USA]
115 CUMC - Columbia University Medical Center
116 UON - University of Nottingham, UK
117 UC Irvine - University of California [Irvine]
118 UNIMI - Università degli Studi di Milano = University of Milan
119 Hotchkiss Brain Institute
120 University of Calgary
121 HiOA - Oslo and Akershus University College of Applied Sciences [Oslo]
122 U1000 - Neuroimagerie en psychiatrie
123 Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney
124 Department of Genomics
125 Aarhus University [Aarhus]
126 Sorlandet Hospital HF
127 University Hospital Mannheim | Universitätsmedizin Mannheim
128 Centre for Advanced Imaging
129 CAI - Centre for Advanced Imaging [Brisbane]
130 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
131 Translational Gerontology Branch
132 Queensland Institute of Medical Research
133 UWA - The University of Western Australia
134 UMM - University of Minnesota [Morris]
135 SyNergy - Munich Cluster for systems neurology [Munich]
136 The University of Texas Medical School at Houston
137 Indiana State University
138 Department of Statistics [Warwick]
139 Stockholm Brain Institute [Stockholm, Sweden]
140 Stockholm University
141 Umeå University = Umeå Universitet
142 University of Texas Health Science Center
143 Department of Clinical Neuropsychology
144 Center for Neurobehavioral Genetics
145 MNI - McConnell Brain Imaging Centre
146 RRI - Rotman Research Institute at the Baycrest Centre
147 SickKids - The Hospital for sick children [Toronto]
148 Department of Psychiatry
149 PITT - University of Pittsburgh
150 PARIETAL - Modelling brain structure, function and variability based on high-field MRI data
151 UC Berkeley - University of California [Berkeley]
152 Department of Psychiatry and Human Behavior [Irvine]
153 Department of Medical and Molecular Genetics
154 Reta Lila Weston Institute, UCL Institute of Neurology
155 Department of Molecular Neuroscience
156 Indiana Alzheimer Disease Center
157 UC / UniCan - Universidad de Cantabria [Santander] = University of Cantabria [Spain] = Université de Cantabrie [Espagne]
158 RTI International - Research Triangle Institute International
159 Centre for Cognitive Ageing and Cognitive Epidemiology
160 MLU - Martin-Luther-Universität Halle Wittenberg
161 Department of Medical and Molecular Genetics
162 King‘s College London
163 Prince of Wales Hospital
164 Karolinska Institute
165 Laureate institute for brain research, Tulsa
166 University of Tulsa
167 CogSci - UC San Diego - Department of Cognitive Sciences [Univ California San Diego]
168 UC San Diego - University of California [San Diego]
169 University of Minnesota Medical School
170 BIDMC - Beth Israel Deaconess Medical Center [Boston]
171 HMS - Harvard Medical School [Boston]
172 Maudsley NHS Foundation Trust and Institute of Psychiatry
173 NIHR Biomedical Research Centre [London]
174 Institute of Neurology [London]
175 Edinburgh Dementia Prevention & Centre for Clinical Brain Sciences
176 Center for Human Genetic Research
177 VA NY Harbor Health Care System
178 Alzheimer Scotland Dementia Research Centre
179 Department of Psychiatry and Behavioral Neuroscience [UC, Cincinnati]
180 University of Cincinnati College of Medicine
181 Marqués de Valdecilla University Hospital [Santander]
182 KFSHRC - King Faisal Specialist Hospital and Resarch Centre [Riyadh, Saudi Arabia]
183 Georgia State University
184 Psychiatry and Leiden Institute for Brain and Cognition
185 LUMC - Leiden University Medical Center
186 Department of Biological Psychology [Amsterdam]
187 Institute for Community Medicine
188 The Centre for Regenerative Medicine
189 Berlin School of Mind and Brain [Berlin]
190 UC San Francisco - University of California [San Francisco]
191 Department of Psychology [Oslo]
192 School of Chemistry, University of Edinburgh
193 Department of Public Health, Erasmus University Medical Centre, Rotterdam
194 Department of Psychiatry and Biobehavioral Sciences
195 University of Exeter
196 Janssen Research & Development
Roberto Toro
Martin Alda
  • Fonction : Auteur
  • PersonId : 945734
Elisabeth B. Binder
Vincent Frouin
Ian B. Hickie
  • Fonction : Auteur
  • PersonId : 941433
Bennett A. Landman
Sanjay Sisodiya
  • Fonction : Auteur
  • PersonId : 890022

Résumé

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
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pasteur-01967166 , version 1 (30-12-2018)

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Paul M. Thompson, Jason L. Stein, Sarah Medland, Derrek D Hibar, Alejandro Arias Vasquez, et al.. The ENIGMA Consortium : large-scale collaborative analyses of neuroimaging and genetic data. Brain imaging and behavior (Brain Imaging Behav), 2014, 8 (2), pp.152-182. ⟨10.1007/s11682-013-9269-5⟩. ⟨pasteur-01967166⟩
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