Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC + CD4 + cell levels: a surrogate marker candidate of HIV-induced intestinal damage - Institut Pasteur Access content directly
Journal Articles Journal of the International AIDS Society Year : 2018

Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC + CD4 + cell levels: a surrogate marker candidate of HIV-induced intestinal damage

Darragh Duffy
Thijs Booiman
  • Function : Author
Neeltje Kootstra
  • Function : Author

Abstract

Combined anti-retroviral therapy (cART) transformed HIV-1 from a deadly disease into a chronic infection, but does not cure HIV infection. It also does not fully restore HIV-induced gut damage unless administered extremely early after infection. Additional biomarkers are needed to evaluate the capacity of therapies aimed at HIV remission/cure to restore HIV-induced intestinal immune damage and limit chronic inflammation. Herein, we aimed to identify a systemic surrogate marker whose levels would reflect gut immune damage such as intestinal Th17 cell loss starting from primary HIV-1 infection.

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Immunology
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pasteur-01880368 , version 1 (24-09-2018)

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Mickaël Ploquin, Armanda Casrouge, Yoann Madec, Nicolas Noël, Béatrice Jacquelin, et al.. Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC + CD4 + cell levels: a surrogate marker candidate of HIV-induced intestinal damage. Journal of the International AIDS Society, 2018, 21 (7), pp.e25144. ⟨10.1002/jia2.25144⟩. ⟨pasteur-01880368⟩
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