Frequent infection of Hylobates pileatus (pileated gibbon) with species-associated variants of hepatitis B virus in Cambodia - Institut Pasteur Access content directly
Journal Articles Journal of General Virology Year : 2005

Frequent infection of Hylobates pileatus (pileated gibbon) with species-associated variants of hepatitis B virus in Cambodia

Jean-Marc Reynes
M. Hunt
  • Function : Author
N. Marx
  • Function : Author
Peter Simmonds
  • Function : Correspondent author
  • PersonId : 910314

Connectez-vous pour contacter l'auteur

Abstract

As well as being distributed widely in human populations, hepatitis B virus (HBV) infections occur frequently in chimpanzee, gibbon and other ape populations in sub-Saharan Africa and South-East Asia. To investigate the frequency and genetic relationships of HBV infecting gibbons in Cambodia, pileated gibbons (Hylobates pileatus) that were originally wild-caught were screened for surface antigen. Twelve of 26 (46 %) were positive, of which 11 were positive for HBV DNA. Phylogenetic analysis of complete genome sequences revealed two distinct genetic groups in the gibbon/orangutan clade. Three were similar to previously described variants infecting H. pileatus in Thailand and eight formed a distinct clade, potentially representing distinct strains of HBV circulating in geographically separated populations in South-East Asia. Because of the ability of HBV to cross species barriers, large reservoirs of infection in gibbons may hamper ongoing attempts at permanent eradication of HBV infection from human populations in South-East Asia through immunization.
Embargoed file
Embargoed file
Visibility date is undetermined
Loading...

Dates and versions

pasteur-01836614 , version 1 (12-07-2018)

Licence

Copyright

Identifiers

Cite

A. A. Sall, S. Starkman, Jean-Marc Reynes, S. Lay, T. Nhim, et al.. Frequent infection of Hylobates pileatus (pileated gibbon) with species-associated variants of hepatitis B virus in Cambodia. Journal of General Virology, 2005, 86 (2), pp.333 - 337. ⟨10.1099/vir.0.80274-0⟩. ⟨pasteur-01836614⟩
47 View
1 Download

Altmetric

Share

Gmail Facebook X LinkedIn More