Application of High-Density DNA Resequencing Microarray for Detection and Characterization of Botulinum Neurotoxin-Producing Clostridia - Institut Pasteur Access content directly
Journal Articles PLoS ONE Year : 2013

Application of High-Density DNA Resequencing Microarray for Detection and Characterization of Botulinum Neurotoxin-Producing Clostridia

Christelle Mazuet
Giulia Kennedy
  • Function : Author
  • PersonId : 920745
Stewart Cole
  • Function : Author
  • PersonId : 846030
Michel-Robert Popoff
Valé Rie Caro
  • Function : Author

Abstract

Clostridium botulinum and related clostridia express extremely potent toxins known as botulinum neurotoxins (BoNTs) that cause severe, potentially lethal intoxications in humans. These BoNT-producing bacteria are categorized in seven major toxinotypes (A through G) and several subtypes. The high diversity in nucleotide sequence and genetic organization of the gene cluster encoding the BoNT components poses a great challenge for the screening and characterization of BoNT-producing strains.
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pasteur-01765377 , version 1 (12-04-2018)

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Jessica Vanhomwegen, Nicolas Berthet, Christelle Mazuet, Ghislaine Guigon, Tatiana Vallaeys, et al.. Application of High-Density DNA Resequencing Microarray for Detection and Characterization of Botulinum Neurotoxin-Producing Clostridia. PLoS ONE, 2013, 8 (6), pp.e67510. ⟨10.1371/journal.pone.0067510⟩. ⟨pasteur-01765377⟩
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