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Journal Articles Cell Host and Microbe Year : 2014

Emergence and Transmission of Arbovirus Evolutionary Intermediates with Epidemic Potential

Veasna Duong
Christine Schmitt
Nir Ben-Tal
  • Function : Author
Philippe Buchy

Abstract

The high replication and mutation rates of RNA viruses can result in the emergence of new epidemic variants. Thus, the ability to follow host-specific evolutionary trajectories of viruses is essential to predict and prevent epidemics. By studying the spatial and temporal evolution of chikungunya virus during natural transmission between mosquitoes and mammals, we have identified viral evolutionary intermediates prior to emergence. Analysis of virus populations at anatomical barriers revealed that the mosquito midgut and salivary gland pose population bottlenecks. By focusing on virus subpopulations in the saliva of multiple mosquito strains, we recapit-ulated the emergence of a recent epidemic strain of chikungunya and identified E1 glycoprotein mutations with potential to emerge in the future. These mutations confer fitness advantages in mosquito and mammalian hosts by altering virion stability and fusogenic activity. Thus, virus evolutionary tra-jectories can be predicted and studied in the short term before new variants displace currently circulating strains.

Domains

Virology

Dates and versions

pasteur-01680236 , version 1 (10-01-2018)

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Cite

Kenneth A Stapleford, Lark L Coffey, Sreyrath Lay, Antonio V Bordería, Veasna Duong, et al.. Emergence and Transmission of Arbovirus Evolutionary Intermediates with Epidemic Potential. Cell Host and Microbe, 2014, 15 (6), pp.706 - 716. ⟨10.1016/j.chom.2014.05.008⟩. ⟨pasteur-01680236⟩
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