Genetics of Type 1A (immune mediated) diabetes - Institut Pasteur Access content directly
Journal Articles Journal of Autoimmunity Year : 2003

Genetics of Type 1A (immune mediated) diabetes

Abstract

Type 1A (immune mediated) diabetes is genetically heterogeneous with important examples for man and animal models with major mutations (autosomal recessive and X-linked recessive) identified as well as oligogenic/polygenic inheritance. For the most common forms of type 1A diabetes alleles of DQ and DR within the major histocompatibility complex are important determinants of disease and allow identification of high risk individuals at birth. Further understanding of both common and rare genetic determinants of type 1A diabetes will contribute to understanding the pathogenesis of diabetes and of autoimmunity.

Dates and versions

pasteur-01643793 , version 1 (21-11-2017)

Identifiers

Cite

Evie Melanitou, Pam Fain, George S Eisenbarth. Genetics of Type 1A (immune mediated) diabetes. Journal of Autoimmunity, 2003, 21 (2), pp.93 - 98. ⟨10.1016/S0896-8411(03)00097-0⟩. ⟨pasteur-01643793⟩

Collections

PASTEUR
38 View
1 Download

Altmetric

Share

Gmail Facebook X LinkedIn More