Candida albicans biofilms: building a heterogeneous, drug-tolerant environment. - Institut Pasteur Access content directly
Journal Articles Current Opinion in Microbiology Year : 2013

Candida albicans biofilms: building a heterogeneous, drug-tolerant environment.

Abstract

Fungi are able to form biofilms on medical implants, causing serious infections. A better understanding of fungal biofilm formation is necessary to develop tools for detection or prevention and to identify new antifungal strategies. This review explores recent advances in the characterization at the molecular level of fungal biofilms, especially those formed by the yeast Candida albicans: the identification of complex transcriptional networks that control their formation; the pivotal role of the extracellular matrix in biofilm antifungal tolerance; and the knowledge gained on the physiology of biofilm cells and heterogeneity within these communities. These findings may help develop new, targeted therapeutic strategies.
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pasteur-01522912 , version 1 (15-05-2017)

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Julie Bonhomme, Christophe D'Enfert. Candida albicans biofilms: building a heterogeneous, drug-tolerant environment.. Current Opinion in Microbiology, 2013, 16 (4), pp.398-403. ⟨10.1016/j.mib.2013.03.007⟩. ⟨pasteur-01522912⟩
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