GABAB Receptors Tune Cortical Feedback to the Olfactory Bulb. - Institut Pasteur Access content directly
Journal Articles Journal of Neuroscience Year : 2016

GABAB Receptors Tune Cortical Feedback to the Olfactory Bulb.


Sensory perception emerges from the confluence of sensory inputs that encode the composition of external environment and top-down feedback that conveys information from higher brain centers. In olfaction, sensory input activity is initially processed in the olfactory bulb (OB), serving as the first central relay before being transferred to the olfactory cortex. In addition, the OB receives dense connectivity from feedback projections, so the OB has the capacity to implement a wide array of sensory neuronal computation. However, little is known about the impact and the regulation of this cortical feedback. Here, we describe a novel mechanism to gate glutamatergic feedback selectively from the anterior olfactory cortex (AOC) to the OB. Combining in vitro and in vivo electrophysiological recordings, optogenetics, and fiber-photometry-based calcium imaging applied to wild-type and conditional transgenic mice, we explore the functional consequences of circuit-specific GABA type-B receptor (GABABR) manipulation. We found that activation of presynaptic GABABRs specifically depresses synaptic transmission from the AOC to OB inhibitory interneurons, but spares direct excitation to principal neurons. As a consequence, feedforward inhibition of spontaneous and odor-evoked activity of principal neurons is diminished. We also show that tunable cortico-bulbar feedback is critical for generating beta, but not gamma, OB oscillations. Together, these results show that GABABRs on cortico-bulbar afferents gate excitatory transmission in a target-specific manner and thus shape how the OB integrates sensory inputs and top-down information.
Fichier principal
Vignette du fichier
Mazoetal.pdf (7.2 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

pasteur-01494505 , version 1 (23-03-2017)



Camille Mazo, Gabriel Lepousez, Antoine Nissant, Matthew T Valley, Pierre-Marie Lledo. GABAB Receptors Tune Cortical Feedback to the Olfactory Bulb.. Journal of Neuroscience, 2016, ⟨10.1523/JNEUROSCI.3823-15.2016⟩. ⟨pasteur-01494505⟩
90 View
208 Download



Gmail Facebook Twitter LinkedIn More