The effects of mosquito saliva on dengue virus infectivity in humans. - Institut Pasteur Access content directly
Journal Articles Current Opinion in Virology Year : 2016

The effects of mosquito saliva on dengue virus infectivity in humans.

Abstract

Arboviruses such as Dengue, Chikungunya, and Zika viruses represent a major public health problem due to globalization and propagation of susceptible vectors worldwide. Arthropod vector-derived salivary factors have the capacity to modulate human cells function by enhancing or suppressing viral replication and, therefore, modify the establishment of local and systemic viral infection. Here, we discuss how mosquito saliva may interfere with Dengue virus (DENV) infection in humans. Identification of saliva factors that enhance infectivity will allow the production of vector-based vaccines and therapeutics that would interfere with viral transmission by targeting arthropod saliva components. Understanding the role of salivary proteins in DENV transmission will provide tools to control not only Dengue but also other arboviral diseases transmitted by the same vectors.
Fichier principal
Vignette du fichier
DMissé_Wichit Current opinion.pdf (822.69 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

pasteur-01453403 , version 1 (16-03-2022)

Licence

Attribution - NonCommercial

Identifiers

Cite

Sineewanlaya Wichit, Pauline Ferraris, Valérie Choumet, Dorothée Missé. The effects of mosquito saliva on dengue virus infectivity in humans.. Current Opinion in Virology, 2016, 21, pp.139-145. ⟨10.1016/j.coviro.2016.10.001⟩. ⟨pasteur-01453403⟩
149 View
660 Download

Altmetric

Share

Gmail Facebook X LinkedIn More