Identification of a Region That Assists Membrane Insertion and Translocation of the Catalytic Domain of Bordetella pertussis CyaA Toxin - Institut Pasteur Access content directly
Journal Articles Journal of Biological Chemistry Year : 2012

Identification of a Region That Assists Membrane Insertion and Translocation of the Catalytic Domain of Bordetella pertussis CyaA Toxin

Abstract

Background: Translocation of the CyaA toxin across plasma membrane is still poorly understood. Results: The region 375– 485 is involved in membrane destabilization in vitro and required for cell intoxication. Conclusion: The region 375– 485 is crucial for membrane insertion and translocation of the catalytic domain of CyaA. Significance: These results provide new insights on the early stages of the cell intoxication process.
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pasteur-01423063 , version 1 (28-12-2016)

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Johanna C. Karst, Robert Barker, Usha Devi, Marcus J. Swann, Marilyne Davi, et al.. Identification of a Region That Assists Membrane Insertion and Translocation of the Catalytic Domain of Bordetella pertussis CyaA Toxin. Journal of Biological Chemistry, 2012, 287 (12), pp.9200 - 9212. ⟨10.1074/jbc.M111.316166⟩. ⟨pasteur-01423063⟩

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