Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency - Institut Pasteur Access content directly
Journal Articles Immunology Letters Year : 2013

Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency

Abstract

The factors that determine the immunodominance, efficacy and almost ubiquitous presence of CD8(+) T-cell responses to the HLA-B27-restricted HIV-1 p24 Gag-derived KK10 epitope remain to be fully elucidated. Here, we show that neither the precursor frequency nor the priming capacity of KK10-reactive CD8(+) T-cells within the naïve pool differ substantially in comparison to other specificities. These data implicate alternative mechanisms in the relative protection conferred by CD8(+) T-cell responses to this epitope.
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pasteur-01420532 , version 1 (20-12-2016)

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Maria Candela Iglesias, Olivia Briceño, Emma Gostick, Arnaud Moris, Céline Meaudre, et al.. Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency. Immunology Letters, 2013, 149 (1-2), pp.119--122. ⟨10.1016/j.imlet.2012.10.002⟩. ⟨pasteur-01420532⟩
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