[Cryptococcus where they are not expected: Five case reports of extra-cerebral and extra-pulmonary cryptococcosis]
Résumé
Cryptococcosis is a serious infection, possibly lethal, of worldwide distribution. It mainly affects immunosuppressed patients resulting with pulmonary and/or meningeal involvements or disseminated infections. Due to the rarity of visceral and osseous infections, and to the absence of specific clinical symptoms, this diagnosis is often deferred. Resulting of diagnostic errors, samples are often directed to the department of pathology and more rarely to the department of mycology. Histopathological examination appears crucial, highlighting encapsulated yeasts with alcian blue staining. Once the diagnosis is performed, an appropriate antifungal therapy must be quickly introduced because these infections are associated with a high mortality rate. The aim of our work was to report five extra-cerebral and extra-pulmonary cryptococcosis cases, to describe their histopathological features, to evoke diagnostic techniques and to discuss the differential diagnoses.
Mots clés
Sacrum
Retrospective Studies
Organ Specificity
Cryptococcal
Meningitis
Male
Lymphatic Diseases
Liver Abscess
Immunohistochimie
Hepatitis B
Chronic
Humans
Immunohistochemistry
Adult
AIDS-Related Opportunistic Infections
Biopsy
Cryptococcosis
Cryptococcus
Dermatomycoses
Discitis
Extra-cerebral
Extracérébral
Extrapulmonaire
Extra-pulmonary