Combined medico-surgical strategy for invasive sino-orbito-cerebral breakthrough fungal infection with Hormographiella aspergillata in an acute leukaemia patient
Résumé
Hormographiella aspergillata is a rare causative agent of invasive filamentous breakthrough infection, mostly arising after echinocandin exposure. We report a neutropenic patient who developed a severe sino-orbito-cerebral H. aspergillata infection while receiving empirical caspofungin, successfully controlled by an aggressive strategy associating surgical debridement and combined high-dose regimen of antifungal drugs.
Mots clés
- Young Adult
- Molecular Sequence Data
- basidiomycosis
- Central Nervous System Fungal Infections
- Combined Modality Therapy
- acute myeloid leukaemia
- Brain
- Drug Resistance
- Male
- Fungal
- Antifungal Agents
- Humans
- Hormographiella aspergillata
- Myeloid
- Neutropenia
- Echinocandins
- Fatal Outcome
- Leukemia
- Acute
- allogeneic haematopoietic stem cell transplantation
- Agaricales
- Debridement
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