An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells - Institut Pasteur Access content directly
Journal Articles Nature Immunology Year : 2004

An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells

Shana Marmon
  • Function : Author
Mary-Jean Sunshine
  • Function : Author
Paul D Rennert
  • Function : Author

Abstract

Lymphoid tissue inducer (LTi) cells are associated with early development of lymph nodes and Peyer's patches. We show here that during fetal life the nuclear hormone receptor RORgamma(t) is expressed exclusively in and is required for the generation of LTi cells. RORgamma(t+) LTi cells provide essential factors, among which lymphotoxin-alpha1beta2 is necessary but not sufficient for activation of the mesenchyma in lymph node and Peyer's patch anlagen. This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues. Comment in Lymphoid organogenesis: getting the green light from RORgamma(t).
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Dates and versions

pasteur-01402773 , version 1 (25-11-2016)

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Gérard Eberl, Shana Marmon, Mary-Jean Sunshine, Paul D Rennert, Yongwon Choi, et al.. An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells. Nature Immunology, 2004, 5 (1), pp.64 - 73. ⟨10.1038/ni1022⟩. ⟨pasteur-01402773⟩

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