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Journal Articles Science Year : 2010

Lineage Relationship Analysis of ROR t+ Innate Lymphoid Cells

Abstract

Abstract Lymphoid tissue-inducer (LTi) cells initiate the development of lymphoid tissues through the activation of local stromal cells in a process similar to inflammation. LTi cells express the nuclear hormone receptor RORγt, which also directs the expression of the proinflammatory cytokine interleukin-17 in T cells. We show here that LTi cells are part of a larger family of proinflammatory RORγt(+) innate lymphoid cells (ILCs) that differentiate from distinct fetal liver RORγt(+) precursors. The fate of RORγt(+) ILCs is determined by mouse age, and after birth, favors the generation of cells involved in intestinal homeostasis and defense. Contrary to RORγt(+) T cells, however, RORγt(+) ILCs develop in the absence of microbiota. Our study indicates that RORγt(+) ILCs evolve to preempt intestinal colonization by microbial symbionts. Comment in Immunology. Innate lymphoid cell relations. [Science. 2010]
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Dates and versions

pasteur-01402753 , version 1 (25-11-2016)

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S. Sawa, M. Cherrier, M. Lochner, N. Satoh-Takayama, H. J. Fehling, et al.. Lineage Relationship Analysis of ROR t+ Innate Lymphoid Cells. Science, 2010, 330 (6004), pp.665 - 669. ⟨10.1126/science.1194597⟩. ⟨pasteur-01402753⟩
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