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Journal Articles Current Opinion in Immunology Year : 2012

The development of LTi cells

Abstract

Lymphoid tissue inducer (LTi) cells are programmed by the mammalian fetus to induce the development of lymph nodes and Peyer's patches. LTi cells share a pro-inflammatory profile with Th17 cells, as well as their requirement for the transcription factor RORγt. We discuss here the latest data on the fetal and post-natal development of LTi cells, and their relationship with the larger family of innate lymphoid cells (ILCs). We suggest that the re-programming of RORγt in a subset of common lymphoid progenitors allowed mammals to develop lymphoid organs before birth, whereas other vertebrates only develop such organs in response to infection or injury.
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pasteur-01402733 , version 1 (25-11-2016)

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Marie Cherrier, Gérard Eberl. The development of LTi cells. Current Opinion in Immunology, 2012, 24 (2), pp.178 - 183. ⟨10.1016/j.coi.2012.02.003⟩. ⟨pasteur-01402733⟩
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