Innate lymphoid cells: A new paradigm in immunology - Institut Pasteur Access content directly
Journal Articles Science Year : 2015

Innate lymphoid cells: A new paradigm in immunology


Innate lymphoid cells (ILCs) are a growing family of immune cells that mirror the phenotypes and functions of T cells. However, in contrast to T cells, ILCs do not express acquired antigen receptors or undergo clonal selection and expansion when stimulated. Instead, ILCs react promptly to signals from infected or injured tissues and produce an array of secreted proteins termed cytokines that direct the developing immune response into one that is adapted to the original insult. The complex cross-talk between microenvironment, ILCs, and adaptive immunity remains to be fully deciphered. Only by understanding these complex regulatory networks can the power of ILCs be controlled or unleashed in order to regulate or enhance immune responses in disease prevention and therapy.
Fichier principal
Vignette du fichier
aaa6566.full.pdf (1.27 Mo) Télécharger le fichier
Origin Publication funded by an institution

Dates and versions

pasteur-01402704 , version 1 (25-11-2016)




G. Eberl, M. Colonna, J. P. Di Santo, A. N. J. Mckenzie. Innate lymphoid cells: A new paradigm in immunology. Science, 2015, 348 (6237), pp.aaa6566. ⟨10.1126/science.aaa6566⟩. ⟨pasteur-01402704⟩


115 View
1232 Download



Gmail Mastodon Facebook X LinkedIn More