Entrapment of Intracytosolic Bacteria by Septin Cage-like Structures - Institut Pasteur Access content directly
Journal Articles Cell Host and Microbe Year : 2010

Entrapment of Intracytosolic Bacteria by Septin Cage-like Structures

Matteo Bonazzi
Mélanie Anne Hamon
Adeline Mallet
  • Function : Author
Roland Brosch
Christophe Zimmer
Anna Sartori


Actin-based motility is used by various pathogens for dissemination within and between cells. Yet host factors restricting this process have not been identified. Septins are GTP-binding proteins that assemble as filaments and are essential for cell division. However, their role during interphase has remained elusive. Here, we report that septin assemblies are recruited to different bacteria that polymerize actin. We observed that intracytosolic Shigella either become compartmentalized in septin cage-like structures or form actin tails. Inactivation of septin caging increases the number of Shigella with actin tails and enhances cell-to-cell spread. TNF-α, a host cytokine produced upon Shigella infection, stimulates septin caging and restricts actin tail formation and cell-to-cell spread. Finally, we show that septin cages entrap bacteria targeted to autophagy. Together, these results reveal an unsuspected mechanism of host defense that restricts dissemination of invasive pathogens.

Dates and versions

pasteur-01376115 , version 1 (04-10-2016)



Serge Mostowy, Matteo Bonazzi, Mélanie Anne Hamon, To Nam Tham, Adeline Mallet, et al.. Entrapment of Intracytosolic Bacteria by Septin Cage-like Structures. Cell Host and Microbe, 2010, 8 (5), pp.433 - 444. ⟨10.1016/j.chom.2010.10.009⟩. ⟨pasteur-01376115⟩
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