Identification of cryptic MHC I-restricted epitopes encoded by HIV-1 alternative reading frames. - Institut Pasteur Access content directly
Journal Articles Journal of Experimental Medicine Year : 2004

Identification of cryptic MHC I-restricted epitopes encoded by HIV-1 alternative reading frames.

Abstract

Human immunodeficiency virus (HIV) 1 major histocompatibility complex (MHC) I-restricted epitopes are widely believed to be derived from viral proteins encoded by primary open reading frames. However, the HIV-1 genome contains alternative reading frames (ARFs) potentially encoding small polypeptides. We have identified a panel of epitopes encoded by ARFs within the gag, pol, and env genes. The corresponding epitopic peptides were immunogenic in mice humanized for MHC-I molecules. In addition, cytotoxic T lymphocytes recognizing these epitopes were found in HIV-infected patients. These results reveal the existence of atypical mechanisms of HIV-1 epitope generation. They indicate that the repertoire of epitopes recognized by the cellular anti-HIV-1 immune response is broader than initially thought. This should be taken into account when designing vaccine strategies aimed at activating these responses.
Fichier principal
Vignette du fichier
1053.full.pdf (356.5 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

pasteur-01372661 , version 1 (27-09-2016)

Licence

Attribution - NonCommercial - ShareAlike

Identifiers

Cite

Sylvain Cardinaud, Arnaud Moris, Michèle Février, Pierre-Simon Rohrlich, Laurence Weiss, et al.. Identification of cryptic MHC I-restricted epitopes encoded by HIV-1 alternative reading frames.. Journal of Experimental Medicine, 2004, 199 (8), pp.1053-63. ⟨10.1084/jem.20031869⟩. ⟨pasteur-01372661⟩

Collections

PASTEUR CNRS
274 View
260 Download

Altmetric

Share

Gmail Facebook X LinkedIn More