Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer. - Institut Pasteur Access content directly
Journal Articles Blood Year : 2006

Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer.

Arnaud Moris
Anthony Pajot
  • Function : Author
Fabien Blanchet
Florence Guivel-Benhassine
Olivier Schwartz
  • Function : Author
  • PersonId : 999827

Abstract

Human immunodeficiency virus (HIV)-specific CD4+ lymphocytes are preferentially infected in HIV-positive individuals. To study this preferential infection, we have derived several HIV-specific (HS) CD4+ clones. We show that in dendritic cells (DCs), HIV virion capture led to major histocompatibility complex class-II (MHC-II)-restricted viral antigen presentation and to activation of HS cells. In contrast, neither cell-free virions nor infected lymphocytes activated HS cells. In DCs, the dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN/CD209), which internalizes virions, promoted MHC-II presentation of HIV antigens. Activation of HS cells by HIV-exposed DCs triggered an efficient viral spread in lymphocytes. CD4+ clones with irrelevant antigenic specificities were not activated by HIV-exposed DCs and poorly supported viral replication under this setting. Our results unravel the mechanisms of MHC-II-restricted HIV antigen presentation by DCs and describe how HIV gains access to the very cells designed by the immune system to counteract this pathogen.

Dates and versions

pasteur-01372632 , version 1 (27-09-2016)

Identifiers

Cite

Arnaud Moris, Anthony Pajot, Fabien Blanchet, Florence Guivel-Benhassine, Margarita Salcedo, et al.. Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer.. Blood, 2006, 108 (5), pp.1643-51. ⟨10.1182/blood-2006-02-006361⟩. ⟨pasteur-01372632⟩

Collections

PASTEUR CNRS
30 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More