Multicentric Castleman Disease in an HHV8-Infected Child Born to Consanguineous Parents With Systematic Review - Institut Pasteur Access content directly
Journal Articles Pediatrics Year : 2012

Multicentric Castleman Disease in an HHV8-Infected Child Born to Consanguineous Parents With Systematic Review

S. Blanche
  • Function : Author

Abstract

Childhood multicentric Castleman disease (MCD) is a rare and unexplained lymphoproliferative disorder. We report a human herpesvirus-8 (HHV-8)-infected child, born to consanguineous Comorian parents, who displayed isolated MCD in the absence of any known immunodeficiency. We also systematically review the clinical features of the 32 children previously reported with isolated and unexplained MCD. The characteristics of this patient and the geographic areas of origin of most previous cases suggest that pediatric MCD is associated with HHV-8 infection. Moreover, as previously suggested for Kaposi sarcoma, MCD in childhood may result from inborn errors of immunity to HHV-8 infection.

Dates and versions

pasteur-01370956 , version 1 (23-09-2016)

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S. Leroy, D. Moshous, O. Cassar, Y. Reguerre, M. Byun, et al.. Multicentric Castleman Disease in an HHV8-Infected Child Born to Consanguineous Parents With Systematic Review. Pediatrics, 2012, 129 (1), pp.e199 - e203. ⟨10.1542/peds.2010-2739⟩. ⟨pasteur-01370956⟩
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