Epidemiologically and clinically relevant Group B Streptococcus isolates do not bind collagen but display enhanced binding to human fibrinogen. - Institut Pasteur Access content directly
Journal Articles Microbes and infection / Institut Pasteur. Year : 2012

Epidemiologically and clinically relevant Group B Streptococcus isolates do not bind collagen but display enhanced binding to human fibrinogen.

Abstract

Group B Streptococcus (GBS) is the leading cause of neonatal septicemia and meningitis. Pili appendages were shown to play a critical role in bacterial adhesion and colonization of human tissues. Recently it was claimed that binding of the pilus-associated adhesin PilA to collagen is a critical, initial step in promoting interactions with the α2β1 integrin expressed on brain endothelial cells. Here we show that strain NCTC10/84 used in this study is not representative for GBS isolates and question the importance of collagen as a critical extracellular matrix component for GBS infections of the central nervous system.

Domains

Bacteriology
Fichier principal
Vignette du fichier
1-s2.0-S1286457912001815-main.pdf (318.38 Ko) Télécharger le fichier
Origin : Explicit agreement for this submission
Comment : Copyright Institut Pasteur
Loading...

Dates and versions

pasteur-01300174 , version 1 (08-04-2016)

Identifiers

Cite

Shaynoor Dramsi, Eric Morello, Claire Poyart, Patrick Trieu-Cuot. Epidemiologically and clinically relevant Group B Streptococcus isolates do not bind collagen but display enhanced binding to human fibrinogen.. Microbes and infection / Institut Pasteur., 2012, 14 (12), pp.1044-8. ⟨10.1016/j.micinf.2012.07.004⟩. ⟨pasteur-01300174⟩
122 View
260 Download

Altmetric

Share

Gmail Facebook X LinkedIn More