RNA and beta-Hemolysin of Group B Streptococcus Induce Interleukin-1 beta ( IL-1 beta) by Activating NLRP3 Inflammasomes in Mouse Macrophages - Institut Pasteur Access content directly
Journal Articles Journal of Biological Chemistry Year : 2014

RNA and beta-Hemolysin of Group B Streptococcus Induce Interleukin-1 beta ( IL-1 beta) by Activating NLRP3 Inflammasomes in Mouse Macrophages

Abstract

The inflammatory cytokine IL-1β is critical for host responses against many human pathogens. Here, we define Group B Streptococcus (GBS)-mediated activation of the Nod-like receptor-P3 (NLRP3) inflammasome in macrophages. NLRP3 activation requires GBS expression of the cytolytic toxin, β-hemolysin, lysosomal acidification, and leakage. These processes allow the interaction of GBS RNA with cytosolic NLRP3. The present study supports a model in which GBS RNA, along with lysosomal components including cathepsins, leaks out of lysosomes and interacts with NLRP3 to induce IL-1β production.

Domains

Bacteriology

Dates and versions

pasteur-01299773 , version 1 (08-04-2016)

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Cite

Rahul Gupta, Shubhendu Ghosh, Brian Monks, Rosane B. Deoliveira, Te-Chen Tzeng, et al.. RNA and beta-Hemolysin of Group B Streptococcus Induce Interleukin-1 beta ( IL-1 beta) by Activating NLRP3 Inflammasomes in Mouse Macrophages. Journal of Biological Chemistry, 2014, 289 (20), pp.13701-13705. ⟨10.1074/jbc.C114.548982⟩. ⟨pasteur-01299773⟩

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