Listeria monocytogenes Dampens the DNA Damage Response - Institut Pasteur Access content directly
Journal Articles PLoS Pathogens Year : 2014

Listeria monocytogenes Dampens the DNA Damage Response

Abstract

The DNA damage response (DDR) is an essential signaling pathway that detects DNA lesions, which constantly occur upon either endogenous or exogenous assaults, and maintains genetic integrity. An infection by an invading pathogen is one such assault, but how bacteria impact the cellular DDR is poorly documented. Here, we report that infection with Listeria monocytogenes induces host DNA breaks. Strikingly, the signature response to these breaks is only moderately activated. We uncover the role of the listerial toxin listeriolysin O (LLO) in blocking the signaling response to DNA breaks through degradation of the sensor Mre11. Knocking out or inactivating proteins involved in the DDR promotes bacterial replication showing the importance of this mechanism for the control of infection. Together, our data highlight that bacterial dampening of the DDR is critical for a successful listerial infection.
Fichier principal
Vignette du fichier
journal.ppat.1004470.pdf (1.31 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

pasteur-01078553 , version 1 (29-10-2014)

Licence

Attribution - NonCommercial - NoDerivatives

Identifiers

Cite

Ascel Samba-Louaka, Jorge Pereira, Marie-Anne Nahori, Veronique Villiers, Ludovic Deriano, et al.. Listeria monocytogenes Dampens the DNA Damage Response. PLoS Pathogens, 2014, 10 (10), pp.e1004470. ⟨10.1371/journal.ppat.1004470⟩. ⟨pasteur-01078553⟩
372 View
383 Download

Altmetric

Share

Gmail Facebook X LinkedIn More