Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles - Institut Pasteur Access content directly
Journal Articles Tetrahedron Year : 2013

Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles

Sandrine Guillou
Yves Louis Janin

Abstract

We report here the transformation of 3/5-trifluoromethylpyrazoles derivative into the corresponding NH-pyrazole-3/5-carboxylic acids. Moreover, from 4- or 5-iodinated-3/5-trifluoromethylpyrazoles building blocks and the use of SuzukieMiyaura or Negishi reactions followed by the trifluoromethyl hydrolysis, we illustrate short and original accesses to many series of NH-pyrazole-3/5-carboxylic acids otherwise difficult to prepare.

Dates and versions

pasteur-00755935 , version 1 (22-11-2012)

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Mikhail S. Ermolenko, Sandrine Guillou, Yves Louis Janin. Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles. Tetrahedron, 2013, 69 (1), pp.257-263. ⟨10.1016/j.tet.2012.10.034⟩. ⟨pasteur-00755935⟩
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