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Journal Articles Immunology Year : 2009

Genetic and epigenetic networks controlling T helper 1 cell differentiation.

Sylvie Maiella
  • Function : Author
Elisabetta Bianchi
Lars Rogge
  • Function : Author

Abstract

Significant progress has been made during the past years in our understanding of the mechanisms that control the differentiation of naïve CD4(+) T cells into effector T-cell subsets with distinct functional properties. Previous work allowed the identification of key molecules involved in regulating this highly complex process, such as cytokines and their receptors, signal transducers and transcription factors. More recently, the emphasis of research in this field has been to elucidate how the multiplicity of signals is integrated to shape a T helper subset-specific gene-expression program controlling differentiation and effector functions. In this review we will highlight advances that have been made in unravelling the genetic and epigenetic networks controlling differentiation of naïve CD4(+) T cells into interferon-gamma(IFN-gamma)-secreting T helper type 1 (Th1) cells.

Domains

Immunology

Dates and versions

pasteur-00509596 , version 1 (13-08-2010)

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Katarzyna Placek, Maryaline Coffre, Sylvie Maiella, Elisabetta Bianchi, Lars Rogge. Genetic and epigenetic networks controlling T helper 1 cell differentiation.. Immunology, 2009, 127 (2), pp.155-62. ⟨10.1111/j.1365-2567.2009.03059.x⟩. ⟨pasteur-00509596⟩
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