CpG Inhibits Pro-B Cell Expansion through a Cathepsin B-Dependent Mechanism. - Institut Pasteur Access content directly
Journal Articles Journal of Immunology Year : 2010

CpG Inhibits Pro-B Cell Expansion through a Cathepsin B-Dependent Mechanism.

Abstract

TLR9 is expressed in cells of the innate immune system, as well as in B lymphocytes and their progenitors. We investigated the effect of the TLR9 ligand CpG DNA on the proliferation of pro-B cells. CpG DNA inhibits the proliferation of pro-B, but not pre-B, cells by inducing caspase-independent cell death through a pathway that requires the expression of cathepsin B. This pathway is operative in Rag-deficient mice carrying an SP6 transgene, in which B lymphopoiesis is compromised, to reduce the size of the B lymphocyte precursor compartments in the bone marrow. Thus, TLR9 signals can regulate B lymphopoiesis in vivo.

Domains

Immunology

Dates and versions

pasteur-00481956 , version 1 (07-05-2010)

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Cite

Ana Inés Lalanne, Ignacio Moraga, Yi Hao, João Pedro Pereira, Nuno L. Alves, et al.. CpG Inhibits Pro-B Cell Expansion through a Cathepsin B-Dependent Mechanism.. Journal of Immunology, 2010, epub ahead of print. ⟨10.4049/jimmunol.0903854⟩. ⟨pasteur-00481956⟩
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