NEDD4-2 associates with gamma(c) and regulates its degradation rate. - Institut Pasteur Access content directly
Journal Articles Biochemical and Biophysical Research Communications Year : 2009

NEDD4-2 associates with gamma(c) and regulates its degradation rate.

Abstract

Interleukin-2 (IL-2) is a cytokine that regulates proliferation, differentiation and survival of various lymphoid cell subsets. Its actions are mediated through its binding to the IL-2 receptor which is composed of three subunits (IL-2Ralpha, IL-2Rbeta and gamma(c)). Only beta and gamma(c) have been shown to transduce intra cellular signals. The gamma(c) chain is shared by the interleukin-2, 4, 7, 9, 15 and 21 receptors, and is essential for lymphocyte functions. The regulation of gamma(c) expression level is therefore critical for the ability of cells to respond to these cytokines. In the present work, we show that the IL-2R constitutively associates with the ubiquitin ligase NEDD4-2, and to a lesser extent NEDD4-1. We identified the specific binding site on gamma(c). And we show that the loss of NEDD4 association on gamma(c) is accompanied by a dramatic increase of the half-life of the receptor subunit.

Dates and versions

pasteur-00409856 , version 1 (13-08-2009)

Identifiers

Cite

Valérie Malardé, Richard Proust, Alice Dautry-Varsat, Franck Gesbert. NEDD4-2 associates with gamma(c) and regulates its degradation rate.. Biochemical and Biophysical Research Communications, 2009, 387 (2), pp.409-13. ⟨10.1016/j.bbrc.2009.07.041⟩. ⟨pasteur-00409856⟩
41 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More