Resource competition as a mechanism for B cell homeostasis. - Institut Pasteur Access content directly
Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 1997

Resource competition as a mechanism for B cell homeostasis.

Abstract

Cellular competition for survival signals offers a cogent and appealing mechanism for the maintenance of cellular homeostasis [Raff, M. C. (1992) Nature (London) 356, 397-400]. We present a theoretical and experimental investigation of the role of competition for resources in the regulation of peripheral B cell numbers. We use formal ecological competition theory, mathematical models of interspecific competition, and competitive repopulation experiments to show that B cells must compete to persist in the periphery and that antigen forms a part of the resources over which B cells compete.

Domains

Immunology

Dates and versions

pasteur-00329067 , version 1 (10-10-2008)

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A. R. Mclean, M. M. Rosado, Fabien Agenes, R. Vasconcellos, Antonio A. Freitas. Resource competition as a mechanism for B cell homeostasis.. Proceedings of the National Academy of Sciences of the United States of America, 1997, 94 (11), pp.5792-7. ⟨10.1073/pnas.94.11.5792⟩. ⟨pasteur-00329067⟩

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