Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice. - Institut Pasteur Access content directly
Journal Articles European Journal of Immunology Year : 2001

Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice.

Abstract

Aging is associated with a decreased production of B cells by the bone marrow and an increased life-span of peripheral B cells. To determine whether the decreased bone marrow B cell production is linked to the increased life-span of B cells in old mice, B cell regeneration following lymphopenia was studied in young and old mice. The rate of bone marrow pre-B cell and of splenic B cell regeneration is slower in irradiated, old compared to irradiated, young recipients of young, congeneic bone marrow. This finding reflects an age-associated defect in the bone marrow microenvironment. As the bone marrow is the only source of a diverse population of B cells, we measured the diversity of the splenic B cell repertoire regenerated following drug-induced lymphopenia in old and young mice. The heterogeneity of mRNA size from IgH complementarity determining region 3 (CDR3) was more restricted in splenic B cells from old compared to young mice providing additional evidence for an age-associated impairment in B cell production by the bone marrow.

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Immunology
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Dates and versions

pasteur-00327510 , version 1 (08-10-2008)

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Fang Li, F. Jin, Antonio Freitas, Paul Szabo, Marc E. Weksler. Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice.. European Journal of Immunology, 2001, 31 (2), pp.500-5. ⟨10.1002/1521-4141(200102)31:2<500::AID-IMMU500>3.0.CO;2-C⟩. ⟨pasteur-00327510⟩
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