Impact of exogenous sequences on the characteristics of an epidemic type 2 recombinant vaccine-derived poliovirus. - Institut Pasteur Access content directly
Journal Articles Journal of Virology Year : 2008

Impact of exogenous sequences on the characteristics of an epidemic type 2 recombinant vaccine-derived poliovirus.

Abstract

Pathogenic circulating vaccine-derived polioviruses (cVDPVs) have become a major obstacle to the successful completion of the global polio eradication program. Most cVDPVs are recombinant between the oral poliovirus vaccine (OPV) and human enterovirus species C (HEV-C). To study the role of HEV-C sequences in the phenotype of cVDPVs, we generated a series of recombinants between a Madagascar cVDPV isolate and its parental OPV type 2 strain. Results indicated that the HEV-C sequences present in this cVDPV contribute to its characteristics, including pathogenicity, suggesting that interspecific recombination contributes to the phenotypic biodiversity of polioviruses and may favor the emergence of cVDPVs.

Domains

Virology

Dates and versions

pasteur-00318592 , version 1 (04-09-2008)

Identifiers

Cite

Franck B. Riquet, Claire Blanchard, Sophie Jegouic, Jean Balanant, Sophie Guillot, et al.. Impact of exogenous sequences on the characteristics of an epidemic type 2 recombinant vaccine-derived poliovirus.. Journal of Virology, 2008, 82 (17), pp.8927-32. ⟨10.1128/JVI.00239-08⟩. ⟨pasteur-00318592⟩
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