Low levels of co-receptor CCR5 are sufficient to permit HIV envelope-mediated fusion with resting CD4 T cells. - Institut Pasteur Access content directly
Journal Articles AIDS. Official journal of the international AIDS Society Year : 2002

Low levels of co-receptor CCR5 are sufficient to permit HIV envelope-mediated fusion with resting CD4 T cells.

Abstract

The susceptibility of phenotypically CCR5-negative resting CD4 T cells for membrane fusion with a CCR5-specific HIV-1 envelope was analysed using a novel sensitive fusion assay. A very low overall density of CCR5 on T cells expressing high levels of CD4 was shown to be sufficient for HIV envelope-mediated membrane fusion. These findings are relevant to the understanding of how HIV-1 R5 strains enter and replicate in resting CD4 T cells in vivo.
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Dates and versions

pasteur-00166869 , version 1 (10-08-2007)

Identifiers

  • HAL Id : pasteur-00166869 , version 1
  • PUBMED : 12441808

Cite

Chantal Chanel, Isabelle Staropoli, Francoise S Baleux, Ali Amara, Agustin Valenzuela-Fernandez, et al.. Low levels of co-receptor CCR5 are sufficient to permit HIV envelope-mediated fusion with resting CD4 T cells.. AIDS. Official journal of the international AIDS Society, 2002, 16 (17), pp.2337-40. ⟨pasteur-00166869⟩

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