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Journal Articles ChemBioChem Year : 2002

Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.

Abstract

Membrane‐permeable nonphosphorylated thymidine analogues (see structure) are active as competitive inhibitors of M. tuberculosis thymidylate kinase (TMPK) as well as of other bacterial TMPKs. A modeling and docking study was used to rationalize the experimental data.

Dates and versions

pasteur-00166196 , version 1 (01-08-2007)

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Sylvie Pochet, Laurence Dugué, Dominique Douguet, Gilles Labesse, Hélène Munier-Lehmann. Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.. ChemBioChem, 2002, 3 (1), pp.108-10. ⟨10.1002/1439-7633(20020104)3:1<108::AID-CBIC108>3.0.CO;2-B⟩. ⟨pasteur-00166196⟩
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