Control of breathing in newborn mice lacking the beta-2 nAChR subunit. - Institut Pasteur Access content directly
Journal Articles Acta Physiologica Scandinavica Year : 2004

Control of breathing in newborn mice lacking the beta-2 nAChR subunit.

Abstract

AIM: To study the ventilatory and arousal/defence responses to hypoxia in newborn mutant mice lacking the beta2 subunit of the nicotinic acetylcholine receptors. METHODS: Breathing variables were measured non-invasively in mutant (n = 31) and wild-type age-matched mice (n = 57) at 2 and 8 days of age using flow barometric whole-body plethysmography. The arousal/defence response to hypoxia was determined using behavioural criteria. RESULTS: On day 2, mutant pups had significantly greater baseline ventilation (16%) than wild-type pups (P < 0.02). Mutant pups had a decreased hypoxic ventilatory declines. Arousal latency was significantly shorter in mutant than in wild-type pups (133 +/- 40 vs. 146 +/- 20 s, respectively, P < 0.026). However, the duration of movement elicited by hypoxia was shorter in mutant than in wild-type pups (14.7 +/- 5.9 vs. 23.0 +/- 10.7 s, respectively, P < 0.0005). Most differences disappeared on P8, suggesting a high degree of functional plasticity. CONCLUSION: The blunted hypoxic ventilatory decline and the shorter arousal latency on day 2 suggested that disruption of the beta2 nicotinic acetylcholine receptors impaired inhibitory processes affecting both the ventilatory and the arousal response to hypoxia during postnatal development.

Domains

Neurobiology

Dates and versions

pasteur-00163485 , version 1 (17-07-2007)

Identifiers

Cite

S. Dauger, E. Durand, G. Cohen, H. Lagercrantz, J.-P. Changeux, et al.. Control of breathing in newborn mice lacking the beta-2 nAChR subunit.. Acta Physiologica Scandinavica, 2004, 182 (2), pp.205-12. ⟨10.1111/j.1365-201X.2004.01345.x⟩. ⟨pasteur-00163485⟩
52 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More