Long-term effects of chronic nicotine exposure on brain nicotinic receptors. - Institut Pasteur Access content directly
Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2007

Long-term effects of chronic nicotine exposure on brain nicotinic receptors.

Morgane Besson
Sylvie Granon
Vincent David
Jean-Pierre Changeux
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  • PersonId : 841245
Philippe Faure

Abstract

Chronic nicotine exposure results in long-term homeostatic regulation of nicotinic acetylcholine receptors (nAChRs) that play a key role in the adaptative cellular processes leading to addiction. However, the relative contribution of the different nAChR subunits in this process is unclear. Using genetically modified mice and pharmacological manipulations, we provide behavioral, electrophysiological, and pharmacological evidence for a long-term mechanism by which chronic nicotine triggers opposing processes differentially mediated by beta2*- vs. alpha7*nAChRs. These data offer previously undescribed insights into the understanding of nicotine addiction and the treatment of several human pathologies by nicotine-like agents chronically acting on beta2*- or alpha7*nAChRs.

Domains

Neurobiology

Dates and versions

pasteur-00161245 , version 1 (10-07-2007)

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Cite

Morgane Besson, Sylvie Granon, Monica Mameli-Engvall, Isabelle Cloëz-Tayarani, Nicolas Maubourguet, et al.. Long-term effects of chronic nicotine exposure on brain nicotinic receptors.. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (19), pp.8155-60. ⟨10.1073/pnas.0702698104⟩. ⟨pasteur-00161245⟩
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