Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway? - Institut Pasteur Access content directly
Journal Articles Nature Reviews Immunology Year : 2005

Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway?

Abstract

The intestinal immune system faces an extraordinary challenge from the large numbers of commensal bacteria and potential pathogens that are restrained by only a single layer of epithelial cells. Here, I discuss evidence that the intestinal immune system develops an extensive network of inducible, reversible lymphoid tissues that contributes to the vital equilibrium between the gut and the bacterial flora. I propose that this network is induced by cryptopatches, which are small clusters of dendritic cells and lymphoid cells that are identical to fetal inducers of lymph-node and Peyer's-patch development.

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Immunology

Dates and versions

pasteur-00161185 , version 1 (10-07-2007)

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Gérard Eberl. Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway?. Nature Reviews Immunology, 2005, 5, pp.413-420. ⟨10.1038/nri1600⟩. ⟨pasteur-00161185⟩
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