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Journal Articles Nature Reviews Neuroscience Year : 2006

Adult neurogenesis and functional plasticity in neuronal circuits.

Pierre-Marie Lledo
Mariana Alonso

Abstract

The adult brain is a plastic place. To ensure that the mature nervous system's control of behaviour is flexible in the face of a varying environment, morphological and physiological changes are possible at many levels, including that of the entire cell. In two areas of the adult brain - the olfactory bulb and the dentate gyrus - new neurons are generated throughout life and form an integral part of the normal functional circuitry. This process is not fixed, but highly modulated, revealing a plastic mechanism by which the brain's performance can be optimized for a given environment. The functional benefits of this whole-cell plasticity, however, remain a matter for debate.

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Neurobiology

Dates and versions

pasteur-00160881 , version 1 (09-07-2007)

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Pierre-Marie Lledo, Mariana Alonso, Matthew S. Grubb. Adult neurogenesis and functional plasticity in neuronal circuits.. Nature Reviews Neuroscience, 2006, 7 (3), pp.179-93. ⟨10.1038/nrn1867⟩. ⟨pasteur-00160881⟩

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