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Article Dans Une Revue iScience Année : 2024

Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2

Timothée Bruel
Isabelle Staropoli
Eduard Baquero

Résumé

Antibodies play a pivotal role in protecting from SARS-CoV-2 infection, but their efficacy is challenged by the continuous emergence of viral variants. In this study, we describe two broadly neutralizing antibodies cloned from the memory B cells of a single convalescent individual after infection with ancestral SARS-CoV-2. Cv2.3194, a resilient class 1 anti-RBD antibody, remains active against Omicron sub-variants up to BA.2.86. Cv2.3132, a near pan-Sarbecovirus neutralizer, targets the heptad repeat 2 membrane proximal region. When combined, Cv2.3194 and Cv2.3132 form a complementary SARS-CoV-2 neutralizing antibody cocktail exhibiting a local dose-dependent synergy. Thus, remarkably robust neutralizing memory B cell antibodies elicited in response to ancestral SARS-CoV-2 infection can withstand viral evolution and immune escape. The cooperative effect of such antibody combination may confer a certain level of protection against the latest SARS-CoV-2 variants.
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pasteur-04645014 , version 1 (11-07-2024)

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Cyril Planchais, Ignacio Fernández, Benjamin Chalopin, Timothée Bruel, Pierre Rosenbaum, et al.. Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2. iScience, 2024, 27 (7), pp.110354. ⟨10.1016/j.isci.2024.110354⟩. ⟨pasteur-04645014⟩
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