Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria
Jérémie Rosain
(1)
,
Anna-Lena Neehus
(1, 2)
,
Jérémy Manry
(1)
,
Rui Yang
(3)
,
Jérémie Le Pen
(4)
,
Wassim Daher
(5)
,
Zhiyong Liu
(3)
,
Yi-Hao Chan
(6)
,
Natalia Tahuil
(7)
,
Özden Türel
(8)
,
Mathieu Bourgey
(9)
,
Masato Ogishi
(3)
,
Jean-Marc Doisne
(10)
,
Helena M Izquierdo
(11)
,
Takayoshi Shirasaki
(12)
,
Tom Le Voyer
(1)
,
Antoine Guérin
(13, 14)
,
Paul Bastard
(1, 4, 15)
,
Marcela Moncada-Vélez
(3, 16)
,
Ji Eun Han
(17)
,
Taushif Khan
(18)
,
Franck Rapaport
(4)
,
Seon-Hui Hong
(4)
,
Andrew Cheung
(4)
,
Kathrin Haake
(2)
,
Barbara C Mindt
(9)
,
Laura Pérez
(19)
,
Quentin Philippot
(1)
,
Danyel Lee
(4, 1)
,
Peng Zhang
(4)
,
Darawan Rinchai
(4)
,
Fatima Al Ali
(18)
,
Manar Mahmoud Ahmad Ata
(18)
,
Mahbuba Rahman
(18)
,
Jessica N Peel
(4)
,
Søren Heissel
(4)
,
Henrik Molina
(4)
,
Yasemin Kendir-Demirkol
(4)
,
Rasheed Bailey
(4)
,
Shuxiang Zhao
(4)
,
Jonathan Bohlen
(1)
,
Mathieu Mancini
(9)
,
Yoann Seeleuthner
(1)
,
Marie Roelens
(20)
,
Lazaro Lorenzo
(1)
,
Camille Soudée
(1)
,
María Elvira Josefina Paz
(7)
,
María Laura González
(7)
,
Mohamed Jeljeli
(21)
,
Jean Soulier
(22)
,
Serge Romana
(20)
,
Anne-Sophie L’honneur
(21)
,
Marie Materna
(1)
,
Rubén Martínez-Barricarte
(23)
,
Mathieu Pochon
(1)
,
Carmen Oleaga-Quintas
(1)
,
Alexandre Michev
(1)
,
Mélanie Migaud
(1)
,
Romain Lévy
(1)
,
Marie-Alexandra Alyanakian
(20)
,
Flore Rozenberg
(21)
,
Carys A Croft
(10)
,
Guillaume Vogt
(24)
,
Jean-François Emile
(25)
,
Laurent Kremer
(26)
,
Cindy S Ma
(13)
,
Jörg H Fritz
(9)
,
Stanley M Lemon
(12)
,
András N Spaan
(4)
,
Nicolas Manel
(11)
,
Laurent Abel
(1)
,
Margaret R Macdonald
(4)
,
Stéphanie Boisson-Dupuis
(1)
,
Nico Marr
(18)
,
Stuart G Tangye
(13)
,
James P Di Santo
(10)
,
Qian Zhang
(1)
,
Shen-Ying Zhang
(1)
,
Charles M Rice
(4)
,
Vivien Béziat
(1)
,
Nico Lachmann
(2)
,
David Langlais
(9)
,
Jean-Laurent Casanova
(1, 4, 27)
,
Philippe Gros
(9)
,
Jacinta Bustamante
(1, 4)
1
Imagine - U1163 -
Imagine - Institut des maladies génétiques (IHU)
2 MHH - Medizinische Hochschule Hannover = Hannover Medical School
3 St. Giles Laboratory of Human Genetics of Infectious Diseases
4 Rockefeller University [New York]
5 IRIM - Institut de Recherche en Infectiologie de Montpellier
6 Yong Loo Lin School of Medicine [Singapore]
7 Hospital del Niño Jesus, San Miguel de Tucumán
8 Bezmiâlem Vakıf Üniversitesi
9 McGill University = Université McGill [Montréal, Canada]
10 Immunité Innée - Innate Immunity
11 Institut Curie [Paris]
12 UNC - University of North Carolina System
13 Garvan Institute of medical research
14 The University of Sydney
15 Hôpital Necker - Enfants Malades [AP-HP]
16 Universidad de Antioquia = University of Antioquia [Medellín, Colombia]
17 ECNU - East China Normal University [Shangaï]
18 Sidra Medicine [Doha, Qatar]
19 “Juan Pedro Garrahan” National Hospital of Pediatrics, Buenos Aires
20 INEM - UM 111 (UMR 8253 / U1151) - Institut Necker Enfants-Malades
21 Hôpital Cochin [AP-HP]
22 AP-HP - Hopital Saint-Louis [AP-HP]
23 Vanderbilt University Medical Center [Nashville]
24 Institut Pasteur de Lille
25 Hôpital Ambroise Paré [AP-HP]
26 UM - Université de Montpellier
27 HHMI - Howard Hughes Medical Institute
2 MHH - Medizinische Hochschule Hannover = Hannover Medical School
3 St. Giles Laboratory of Human Genetics of Infectious Diseases
4 Rockefeller University [New York]
5 IRIM - Institut de Recherche en Infectiologie de Montpellier
6 Yong Loo Lin School of Medicine [Singapore]
7 Hospital del Niño Jesus, San Miguel de Tucumán
8 Bezmiâlem Vakıf Üniversitesi
9 McGill University = Université McGill [Montréal, Canada]
10 Immunité Innée - Innate Immunity
11 Institut Curie [Paris]
12 UNC - University of North Carolina System
13 Garvan Institute of medical research
14 The University of Sydney
15 Hôpital Necker - Enfants Malades [AP-HP]
16 Universidad de Antioquia = University of Antioquia [Medellín, Colombia]
17 ECNU - East China Normal University [Shangaï]
18 Sidra Medicine [Doha, Qatar]
19 “Juan Pedro Garrahan” National Hospital of Pediatrics, Buenos Aires
20 INEM - UM 111 (UMR 8253 / U1151) - Institut Necker Enfants-Malades
21 Hôpital Cochin [AP-HP]
22 AP-HP - Hopital Saint-Louis [AP-HP]
23 Vanderbilt University Medical Center [Nashville]
24 Institut Pasteur de Lille
25 Hôpital Ambroise Paré [AP-HP]
26 UM - Université de Montpellier
27 HHMI - Howard Hughes Medical Institute
Jérémie Rosain
- Fonction : Auteur
- PersonId : 802711
- ORCID : 0000-0002-2822-161X
Jean-Marc Doisne
- Fonction : Auteur
- PersonId : 746758
- IdHAL : jean-marc-doisne
- ORCID : 0000-0001-6714-1308
Nicolas Manel
- Fonction : Auteur
- PersonId : 759207
- ORCID : 0000-0002-1481-4430
- IdRef : 095062467
Jean-Laurent Casanova
- Fonction : Auteur
- PersonId : 756193
- ORCID : 0000-0002-7782-4169
- IdRef : 073388726
Résumé
Highlights d Inherited complete human IRF1 deficiency underlies severe mycobacterial disease d Human IRF1 is essential for IFN-g-dependent macrophagic immunity to mycobacteria d Human IRF1 is essential for IFN-g-and STAT1-dependent immunity to mycobacteria d Human IRF1 is largely redundant for IFN-a/b-dependent antiviral intrinsic immunity Authors Je ´re ´mie Rosain,
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