Diving into the complexity of the spirochetal endoflagellum - Institut Pasteur
Journal Articles (Review Article) Trends in Microbiology Year : 2023

Diving into the complexity of the spirochetal endoflagellum

Abstract

Spirochaetes, a phylum that includes medically important pathogens such as the causative agents of Lyme disease, syphilis, and leptospirosis, are in many ways highly unique bacteria. Their cell morphology, subcellular organization, and metabolism reveal atypical features. Spirochetal motility is also singular, dependent on the presence of periplasmic flagella or endoflagella, inserted subterminally at cell poles and not penetrating the outer membrane and elongating outside the cell as in enterobacteria. In this review we present a comprehensive comparative genomics analysis of endoflagellar systems in spirochetes, highlighting recent findings on the flagellar basal body and filament. Continued progress in understanding the function and architecture of spirochetal flagella is uncovering paradigm-shifting mechanisms of bacterial motility.
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pasteur-04117804 , version 1 (05-06-2023)

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Fabiana San Martin, Lenka Fule, Gregorio Iraola, Alejandro Buschiazzo, Mathieu Picardeau. Diving into the complexity of the spirochetal endoflagellum. Trends in Microbiology, 2023, 31 (3), pp.294-307. ⟨10.1016/j.tim.2022.09.010⟩. ⟨pasteur-04117804⟩
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