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Pré-Publication, Document De Travail Année : 2022

A widespread family of phage-inducible chromosomal islands only steals bacteriophage tails to spread in nature

Résumé

Phage satellites interfere with helper phage packaging through the production of small-capsids, where only satellites can be packaged. So far, in all the analysed systems, the satellite-sized capsids are composed of phage proteins. Here we report the first demonstration that a family of phage-inducible chromosomal island (PICIs), a type of satellites, encodes all the proteins required for both the production of the small-sized capsids and the exclusive packaging of the PICIs into these capsids. Therefore, this new family, that we have named cf-PICIs ( c apsid forming PICIs), only requires phage tails to generate infective PICI particles. Remarkably, the representative cf-PICI reproduces without cost for their helper phages, suggesting that the relationship between these elements is not parasitic but commensalistic. Finally, our phylogenomic studies indicate that cf-PICIs are present both in Gram-positive and Gram-negative bacteria and have evolved at least three times independently to spread widely into the satellite universe.
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Dates et versions

pasteur-03952543 , version 1 (03-11-2022)
pasteur-03952543 , version 2 (23-01-2023)

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Nasser Alqurainy, Laura Miguel-Romero, Jorge Moura de Sousa, John Chen, Eduardo P.C. Rocha, et al.. A widespread family of phage-inducible chromosomal islands only steals bacteriophage tails to spread in nature. 2022. ⟨pasteur-03952543v1⟩
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