Using zebrafish to understand reciprocal interactions between the nervous and immune systems and the microbial world - Institut Pasteur Access content directly
Journal Articles Journal of Neuroinflammation Year : 2022

Using zebrafish to understand reciprocal interactions between the nervous and immune systems and the microbial world

Abstract

Animals rely heavily on their nervous and immune systems to perceive and survive within their environment. Despite the traditional view of the brain as an immunologically privileged organ, these two systems interact with major consequences. Furthermore, microorganisms within their environment are major sources of stimuli and can establish relationships with animal hosts that range from pathogenic to mutualistic. Research from a variety of human and experimental animal systems are revealing that reciprocal interactions between microbiota and the nervous and immune systems contribute significantly to normal development, homeostasis, and disease. The zebrafish has emerged as an outstanding model within which to interrogate these interactions due to facile genetic and microbial manipulation and optical transparency facilitating in vivo imaging. This review summarizes recent studies that have used the zebrafish for analysis of bidirectional control between the immune and nervous systems, the nervous system and the microbiota, and the microbiota and immune system in zebrafish during development that promotes homeostasis between these systems. We also describe how the zebrafish have contributed to our understanding of the interconnections between these systems during infection in fish and how perturbations may result in pathology.
Fichier principal
Vignette du fichier
2022_Levraud_Neuro-Immuno_microbio review.pdf (704.04 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

pasteur-03696037 , version 1 (15-06-2022)

Licence

Attribution - NonCommercial

Identifiers

Cite

Jean-Pierre Levraud, John F Rawls, Anne E Clatworthy. Using zebrafish to understand reciprocal interactions between the nervous and immune systems and the microbial world. Journal of Neuroinflammation, 2022, 19 (1), pp.170. ⟨10.1186/s12974-022-02506-x⟩. ⟨pasteur-03696037⟩
74 View
91 Download

Altmetric

Share

Gmail Facebook X LinkedIn More