Olfactory outcomes in Zika virus-associated Guillain-Barré syndrome - Institut Pasteur Access content directly
Journal Articles European Journal of Neurology Year : 2022

Olfactory outcomes in Zika virus-associated Guillain-Barré syndrome


Background: Zika Virus (ZIKV) infection has been associated with Guillain-Barré Syndrome (GBS). Yet, little is known about the consequence of ZIKV infection on olfaction in humans. Methods: Just right before the COVID-19 outbreak, we prospectively investigated the olfacto-ry capacities of 19 patients with ZIKV-associated GBS from the French West Indies and com-pared them to 9 controls from the same population, with a GBS of similar severity but inde-pendent of Zika infection. To provide further evidence that ZIKV infection induces smell altera-tion, we investigated the consequences of ZIKV infection on olfactory abilities using a mouse model. Results: Patients with GBS-Zika+ had a poorer olfactory function than GBS-non-Zika, even one to two years after the acute phase. The proportion of patients with hyposmia was signifi-cantly higher in GBS-Zika+ than in GBS-non-Zika group (68.4% versus 22.2%, P=0.042). These deficits were characterized by lower threshold and identification scores and were inde-pendent from GBS severity. Additionally, ZIKV infection was found to impair olfaction in immu-nodeficient mice infected with ZIKV. High viral load was observed in their olfactory system and downstream brain structures. ZIKV promoted both cellular damages in the olfactory neuroepi-thelium and protracted inflammation of the olfactory bulb, likely accounting for smell alteration. Conclusions: Patients with ZIKV-related GBS had a poorer long-term olfactory function than patients with GBS-non-Zika and ZIKV-infected mice are hyposmic. These observations sug-gest that ZIKV belongs to the list of viruses affecting the olfactory system. Clinical evaluation of the olfactory system should be considered for ZIKV-infected patients.
Fichier principal
Vignette du fichier
Lazarini et al .pdf (170.65 Ko) Télécharger le fichier
Fig 1.tiff (406.97 Ko) Télécharger le fichier
Fig 3.tiff (2.33 Mo) Télécharger le fichier
Supporting Information.pdf (552.99 Ko) Télécharger le fichier
Table 1.pdf (217.74 Ko) Télécharger le fichier
fig 2.tiff (541.61 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

pasteur-03695748 , version 1 (15-06-2022)


Attribution - NonCommercial



Françoise Lazarini, Annie Lannuzel, André Cabié, Vincent Michel, Yoann Madec, et al.. Olfactory outcomes in Zika virus-associated Guillain-Barré syndrome. European Journal of Neurology, 2022, 29 (9), pp.2823-2831. ⟨10.1111/ene.15444⟩. ⟨pasteur-03695748⟩
151 View
147 Download



Gmail Facebook X LinkedIn More