Human plague: An old scourge that needs new answers - Institut Pasteur Access content directly
Journal Articles PLoS Neglected Tropical Diseases Year : 2020

Human plague: An old scourge that needs new answers

Christian Demeure
Peter Horby
  • Function : Author
Javier Pizarro-Cerdá
Guia Carrara
  • Function : Author


Yersinia pestis, the bacterial causative agent of plague, remains an important threat to human health. Plague is a rodent-borne disease that has historically shown an outstanding ability to colonize and persist across different species, habitats, and environments while provoking sporadic cases, outbreaks, and deadly global epidemics among humans. Between September and November 2017, an outbreak of urban pneumonic plague was declared in Madagascar, which refocused the attention of the scientific community on this ancient human scourge. Given recent trends and plague’s resilience to control in the wild, its high fatality rate in humans without early treatment, and its capacity to disrupt social and healthcare systems, human plague should be considered as a neglected threat. A workshop was held in Paris in July 2018 to review current knowledge about plague and to identify the scientific research priorities to eradicate plague as a human threat. It was concluded that an urgent commitment is needed to develop and fund a strong research agenda aiming to fill the current knowledge gaps structured around 4 main axes: (i) an improved understanding of the ecological interactions among the reservoir, vector, pathogen, and environment; (ii) human and societal responses; (iii) improved diagnostic tools and case management; and (iv) vaccine development. These axes should be cross-cutting, translational, and focused on delivering context-specific strategies. Results of this research should feed a global control and prevention strategy within a “One Health” approach.
Fichier principal
Vignette du fichier
2020 Valles PLoS NTD.pdf (1.28 Mo) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

pasteur-02928741 , version 1 (02-09-2020)





Xavier Vallès, Nils Chr. Stenseth, Christian Demeure, Peter Horby, Paul S. Mead, et al.. Human plague: An old scourge that needs new answers. PLoS Neglected Tropical Diseases, 2020, 14 (8), pp.e0008251. ⟨10.1371/journal.pntd.0008251⟩. ⟨pasteur-02928741⟩
90 View
94 Download



Gmail Facebook X LinkedIn More