An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling - Institut Pasteur Access content directly
Journal Articles Cell Host and Microbe Year : 2019

An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling

Frédéric Tangy
Fabrizia Stavru
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  • PersonId : 1014629

Abstract

RNA-binding proteins (RBPs) perform key cellular activities by controlling the function of bound RNAs. The widely held assumption that RBPs are strictly intracellular has been challenged by the discovery of secreted RBPs. However, extracellular RBPs have been described in eukaryotes, while secreted bacterial RBPs have not been reported. Here, we show that the bacterial pathogen Listeria monocytogenes secretes a small RBP that we named Zea. We show that Zea binds a subset of L. monocytogenes RNAs, causing their accumulation in the extracellular medium. Furthermore, during L. monocytogenes infection, Zea binds RIG-I, the non-self-RNA innate immunity sensor, potentiating interferon-β production. Mouse infection studies reveal that Zea affects L. monocytogenes virulence. Together, our results unveil that bacterial RNAs can be present extracellularly in association with RBPs, acting as “social RNAs” to trigger a host response during infection.
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pasteur-02390001 , version 1 (02-12-2019)

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Alessandro Pagliuso, To Nam Tham, Eric Allemand, Stevens Robertin, Bruno Dupuy, et al.. An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling. Cell Host and Microbe, 2019, 26 (6), pp.823-835.e11. ⟨10.1016/j.chom.2019.10.004⟩. ⟨pasteur-02390001⟩
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