Viruses of archaea: Structural, functional, environmental and evolutionary genomics - Institut Pasteur Access content directly
Journal Articles Virus Research Year : 2018

Viruses of archaea: Structural, functional, environmental and evolutionary genomics


Viruses of archaea represent one of the most enigmatic parts of the virosphere. Most of the characterized archaeal viruses infect extremophilic hosts and display remarkable diversity of virion morphotypes, many of which have never been observed among viruses of bacteria or eukaryotes. The uniqueness of the virion morphologies is matched by the distinctiveness of the genomes of these viruses, with ∼75% of genes encoding unique proteins, refractory to functional annotation based on sequence analyses. In this review, we summarize the state-of-the-art knowledge on various aspects of archaeal virus genomics. First, we outline how structural and functional genomics efforts provided valuable insights into the functions of viral proteins and revealed intricate details of the archaeal virus-host interactions. We then highlight recent metagenomics studies, which provided a glimpse at the diversity of uncultivated viruses associated with the ubiquitous archaea in the oceans, including Thaumarchaeota, Marine Group II Euryarchaeota, and others. These findings, combined with the recent discovery that archaeal viruses mediate a rapid turnover of thaumarchaea in the deep sea ecosystems, illuminate the prominent role of these viruses in the biosphere. Finally, we discuss the origins and evolution of archaeal viruses and emphasize the evolutionary relationships between viruses and non-viral mobile genetic elements. Further exploration of the archaeal virus diversity as well as functional studies on diverse virus-host systems are bound to uncover novel, unexpected facets of the archaeal virome.
Fichier principal
Vignette du fichier
Viruses of archaea_Structural_functional_environmental and evolutionary genomicsVC.pdf (2.58 Mo) Télécharger le fichier
Table S1.pdf (179.13 Ko) Télécharger le fichier
Table S2_R1.pdf (316.48 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

pasteur-01977349 , version 1 (10-06-2020)



Mart Krupovic, Virginija Cvirkaite-Krupovic, Jaime Iranzo, David Prangishvili, Eugene Koonin. Viruses of archaea: Structural, functional, environmental and evolutionary genomics. Virus Research, 2018, 244, pp.181-193. ⟨10.1016/j.virusres.2017.11.025⟩. ⟨pasteur-01977349⟩


74 View
222 Download



Gmail Facebook X LinkedIn More