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Journal Articles AIDS (London, England) Year : 2016

Polyfunctional HIV-specific T cells in Post-Treatment Controllers

Anrs Visconti Study Group
  • Function : Author

Abstract

To further understand the exceptional HIV-1 control observed in Post-Treatment Controllers (PTCs) from the Virological and Immunological Sustained CONtrol after Treatment Interruption study we investigated their HIV-specific T-cell responses. Polyfunctionality of HIV-specific CD4 and CD8 T cells and the ratios of HIV-specific CD4 T cells per infected cells were similar in post-treatment controllers, continuously early-treated patients and long-term non-progressors Overall early treatment appears to preserve robust HIV-specific CD4 T cells, which might contribute to the posttreatment control of HIV.

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Immunology
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Dates and versions

pasteur-01420411 , version 1 (20-12-2016)

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Assia Samri, Charlin Bacchus-Souffan, Laurent Hocqueloux, Véronique Avettand-Fenoel, Benjamin Descours, et al.. Polyfunctional HIV-specific T cells in Post-Treatment Controllers. AIDS (London, England), 2016, 30 (15), pp.2299--2302. ⟨10.1097/QAD.0000000000001195⟩. ⟨pasteur-01420411⟩
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