Human immunodeficiency virus type 1 entry into macrophages mediated by macropinocytosis. - Institut Pasteur Access content directly
Journal Articles Journal of Virology Year : 2001

Human immunodeficiency virus type 1 entry into macrophages mediated by macropinocytosis.

Marie-Christine Prevost
Caroline Petit
Emmanuel Perret
  • Function : Author
Olivier Schwartz
  • Function : Author
  • PersonId : 999827

Abstract

Whereas human immunodeficiency virus (HIV) infects various cell types by fusion at the plasma membrane, we observed a different entry route in human primary macrophages, in which macropinocytosis is active. Shortly after exposure of macrophages to HIV-1 and irrespective of viral envelope-receptor interactions, particles were visible in intracellular vesicles, which were identified as macropinosomes. Most virions appeared subsequently degraded. However, fusion leading to capsid release in the cytosol and productive infection could take place inside vesicles when particles were properly enveloped. These observations provide new insights into HIV-1 interactions with a cell target relevant to pathogenesis. They may have implications for the design of soluble inhibitors aimed at interfering with the fusion or entry processes.

Dates and versions

pasteur-01372716 , version 1 (27-09-2016)

Identifiers

Cite

Valérie Maréchal, Marie-Christine Prevost, Caroline Petit, Emmanuel Perret, Jean-Michel Heard, et al.. Human immunodeficiency virus type 1 entry into macrophages mediated by macropinocytosis.. Journal of Virology, 2001, 75 (22), pp.11166-77. ⟨10.1128/JVI.75.22.11166-11177.2001⟩. ⟨pasteur-01372716⟩

Collections

PASTEUR CNRS
51 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More