Immunogenicity and tolerance following HIV-1/HBV plant-based oral vaccine administration. - Institut Pasteur Access content directly
Journal Articles Vaccine Year : 2008

Immunogenicity and tolerance following HIV-1/HBV plant-based oral vaccine administration.

Abstract

Transgenic tobacco plants expressing a HIV-1 polyepitope associated with hepatitis B (HBV) virus-like particles (VLPs) were previously described. It is demonstrated here that oral administration of these transgenic plants to humanized HSB mice to boost DNA-priming can elicit anti-HIV-1 specific CD8+ T cell activation detectable in mesenteric lymph nodes. Nevertheless, a significant regulatory T cell activation was induced in vivo by the vaccination protocols. The balance between tolerance and immunogenicity remains the main concern in the proof of concept of plant-based vaccine.

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Vaccinology

Dates and versions

pasteur-00363402 , version 1 (23-02-2009)

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Denise Guetard, Raffaella Greco, Minerva Cervantes Gonzalez, Susanna Celli, Anna Kostrzak, et al.. Immunogenicity and tolerance following HIV-1/HBV plant-based oral vaccine administration.. Vaccine, 2008, 26 (35), pp.4477-85. ⟨10.1016/j.vaccine.2008.06.059⟩. ⟨pasteur-00363402⟩

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